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1.
J Am Vet Med Assoc ; 259(4): 401-405, 2021 Aug 15.
Article in English | MEDLINE | ID: mdl-34337962

ABSTRACT

CASE DESCRIPTION: A 2-year-old 5.1-kg (11.2-lb) castrated male Siberian cat was examined because of a history of an abnormal right pelvic limb gait and a 4- to 5-month history of progressive constipation. Radiographs obtained by the referring veterinarian showed an osteoproductive and osteolytic bony lesion that involved the right ischium and filled the obturator foramen. CLINICAL FINDINGS: A hard mass was palpable in the right inguinal area, and rectal examination revealed a smooth bony mass on the ventral aspect of the right pelvic floor with marked reduction in the pelvic canal space. A 3.9 × 3 × 4.6-cm, mineralized mass bridging the right obturator foramen was present on CT images. The ventral component of the mass was slightly larger than its dorsal component, and lysis of the right pubic bone was present. There was no obvious soft tissue involvement. TREATMENT AND OUTCOME: A limb salvage procedure involving internal hemipelvectomy with ipsilateral ischiectomy, contralateral partial ischiectomy, ipsilateral partial acetabulectomy, and femoral head and neck excision was performed. Histologic examination revealed that the mass was an osteochondroma. The cat recovered well and had good functional limb use immediately after surgery. The cat was still alive 1 year after surgery with good limb use. CLINICAL RELEVANCE: Internal hemipelvectomy involving ischiectomy, partial acetabulectomy, and femoral head and neck excision can result in a good functional outcome in cats if the procedure is planned appropriately with a full understanding of the regional anatomy and adherence to surgical oncologic principles.


Subject(s)
Bone Neoplasms , Cat Diseases , Hemipelvectomy , Osteochondroma , Animals , Bone Neoplasms/veterinary , Cat Diseases/surgery , Cats , Femur Head , Hemipelvectomy/veterinary , Male , Osteochondroma/veterinary , Pelvis , Treatment Outcome
2.
Vet Surg ; 50(4): 740-747, 2021 May.
Article in English | MEDLINE | ID: mdl-33772819

ABSTRACT

OBJECTIVE: To report the signalment, staging, surgical treatment, and survival time of juvenile dogs treated surgically for oral squamous cell carcinoma (OSCC). STUDY DESIGN: Retrospective study. ANIMALS OR SAMPLE POPULATION: Twenty-five dogs, <2 years of age with OSCC treated with surgery. METHODS: Cases were solicited from the Veterinary Society of Surgical Oncology. Data retrieved included sex, breed, age, weight, clinical signs, tumor location, preoperative diagnostics and staging, histopathological diagnosis with margin evaluation, disease-free interval, and date and cause of death. A minimum follow-up time of 3 months was required for inclusion. RESULTS: Eighteen dogs were <12 months of age, and seven were <24 months. Various breeds were represented, with a mean body weight of 22.3 ± 14.4 kg. No dogs had evidence of metastatic disease prior to surgery. All dogs underwent partial maxillectomy or mandibulectomy. Histological margins were complete in 24 dogs and incomplete in one. No dogs had evidence of metastatic disease or tumor recurrence. The median follow-up time was 1556 days (92 to 4234 days). All dogs were alive at the last follow-up except for one documented death, due to dilated cardiomyopathy. Median disease-specific survival time was not reached. CONCLUSION: The prognosis after wide surgical excision of OSCC in juvenile dogs was excellent. CLINICAL SIGNIFICANCE: OSCC in juvenile dogs can be effectively treated with surgery alone.


Subject(s)
Dog Diseases/surgery , Head and Neck Neoplasms/veterinary , Squamous Cell Carcinoma of Head and Neck/veterinary , Age Factors , Animals , Dog Diseases/diagnosis , Dogs , Female , Head and Neck Neoplasms/diagnosis , Head and Neck Neoplasms/surgery , Male , Prognosis , Retrospective Studies , Squamous Cell Carcinoma of Head and Neck/diagnosis , Squamous Cell Carcinoma of Head and Neck/surgery , Treatment Outcome
3.
Vet Surg ; 50(3): 607-614, 2021 Apr.
Article in English | MEDLINE | ID: mdl-33634898

ABSTRACT

OBJECTIVE: To describe preoperative autologous blood donation (PABD) and transfusion in dogs undergoing elective surgical oncology procedures with a high risk of intraoperative hemorrhage. STUDY DESIGN: Prospective study. ANIMALS: Twelve dogs. METHODS: Dogs undergoing surgical oncology procedures associated with a high risk of hemorrhage were enrolled. Blood was collected a minimum of 6 days before surgery and separated into fresh frozen plasma (FFP) and packed red blood cells (pRBC). Dogs received FFP at the start of surgery and pRBC intraoperatively when hemorrhage ensued. The mean packed cell volume/total solids (PCV/TS) were calculated on the day of PABD preoperatively, immediately postoperatively, and 24 hours after transfusion. The dogs were monitored for transfusion-related adverse reactions, including hyperthermia, hypotension, tachycardia, bradycardia, pale mucous membranes, prolonged capillary refill time, or tachypnea/dyspnea. RESULTS: Dogs enrolled in the study underwent mandibulectomy, maxillectomy, chest wall resection, and liver lobectomy. Ten of the 12 dogs that underwent PABD received autologous transfusion at first signs of hemorrhage intraoperatively. Iatrogenic anemia was noted in two dogs (PCV 30% and 31%). The mean PCV/TS levels on the day of blood collection, preoperatively, immediately postoperatively (after transfusion), and 24 hours posttransfusion were 45.1%/7.1 g/dL, 42.2%/6.73 g/dL, 33.2%/5.42 g/dL, and 36.5%/5.65 g/dL, respectively. No dog developed transfusion-related complications. CONCLUSION: Preoperative autologous blood donation was well tolerated and led to uneventful autologous transfusion in 10 of 12 dogs. CLINICAL SIGNIFICANCE: Preoperative autologous blood donation and autologous transfusion are feasible for dogs undergoing elective surgical procedures with a high risk of hemorrhage.


Subject(s)
Blood Donors , Blood Transfusion, Autologous/veterinary , Elective Surgical Procedures/veterinary , Hemorrhage/veterinary , Intraoperative Complications/veterinary , Preoperative Period , Animals , Blood Transfusion, Autologous/methods , Dogs , Elective Surgical Procedures/methods , Female , Hemorrhage/etiology , Hemorrhage/prevention & control , Intraoperative Complications/prevention & control , Male , Prospective Studies , Surgical Oncology/methods
4.
Vet Comp Oncol ; 19(4): 724-734, 2021 Dec.
Article in English | MEDLINE | ID: mdl-32619339

ABSTRACT

Perioperative administration of desmopressin has shown to significantly decrease rates of local recurrence and metastasis, and increase survival times in dogs with grade II and III mammary carcinomas. The objective of this study was to compare the oncologic outcome of cats with mammary carcinoma treated with bilateral mastectomy with or without perioperative administration of desmopressin. Medical records from nine veterinary institutions were searched to identify cats diagnosed with mammary carcinoma treated with bilateral mastectomy. Sixty cats treated with single-session or staged bilateral mastectomy were included. There were no significant differences in oncologic outcomes found between cats treated and not treated with desmopressin. No adverse effects were seen in any of the cats treated with perioperative desmopressin. Postoperative complications occurred in 18 cats (38.3%) treated with single-session bilateral mastectomy and in three cats (23.1%) treated with staged bilateral mastectomy (P = .48). Histologic grade and a modification of a proposed five-stage histologic staging system were both prognostic for disease-free interval. Incomplete histologic excision was associated with significantly increased rates of metastasis and tumour progression, and a shorter median survival time (MST). Cats that developed local recurrence also had a significantly shorter MST. The results of this study do not support the use of perioperative desmopressin to improve outcome when performing bilateral mastectomy for the treatment of mammary carcinoma in cats.


Subject(s)
Carcinoma , Cat Diseases , Deamino Arginine Vasopressin , Mammary Neoplasms, Animal , Animals , Carcinoma/drug therapy , Carcinoma/surgery , Carcinoma/veterinary , Cat Diseases/drug therapy , Cat Diseases/surgery , Cats , Deamino Arginine Vasopressin/administration & dosage , Deamino Arginine Vasopressin/therapeutic use , Female , Mammary Neoplasms, Animal/drug therapy , Mammary Neoplasms, Animal/surgery , Mastectomy/veterinary , Perioperative Care
5.
Am J Vet Res ; 81(9): 747-754, 2020 Sep.
Article in English | MEDLINE | ID: mdl-33112170

ABSTRACT

OBJECTIVE: To determine the optimal energy profile for and to assess the feasibility and efficacy of ultrasonographic and laparoscopic guidance for microwave ablation (MWA) of clinically normal canine ovaries. SAMPLE: 44 extirpated ovaries from 22 healthy dogs. PROCEDURES: In the first of 2 trials, 13 dogs underwent oophorectomy by routine laparotomy. Extirpated ovaries underwent MWA at 45 W for 60 (n = 11) or 90 (12) seconds; 3 ovaries did not undergo MWA and served as histologic controls. Ovaries were histologically evaluated for cell viability. Ovaries without viable cells were categorized as completely ablated. Histologic results were used to identify the optimal MWA protocol for use in the subsequent trial. In the second trial, the ovaries of 9 dogs underwent MWA at 45 W for 90 seconds in situ. Ultrasonographic guidance for MWA was deemed unfeasible after evaluation of 1 ovary. The remaining 17 ovaries underwent MWA with laparoscopic guidance, after which routine laparoscopic oophorectomy was performed. Completeness of ablation was histologically assessed for all ovaries. RESULTS: 2 ovaries were excluded from the trial 1 analysis because of equivocal cell viability. Six of 11 ovaries and 10 of 10 ovaries that underwent MWA for 60 and 90 seconds, respectively, were completely ablated. In trial 2, laparoscopic-guided MWA resulted in complete ablation for 12 of 17 ovaries. Dissection of the ovarian bursa for MWA probe placement facilitated complete ablation. CONCLUSIONS AND CLINICAL RELEVANCE: Laparoscopic-guided MWA at 45 W for 90 seconds was feasible, safe, and effective for complete ablation of clinically normal ovaries in dogs.


Subject(s)
Catheter Ablation , Laparoscopy , Animals , Catheter Ablation/veterinary , Dogs , Feasibility Studies , Female , Laparoscopy/veterinary , Microwaves , Ovary/diagnostic imaging , Ovary/surgery , Radiofrequency Ablation/veterinary , Treatment Outcome
6.
Can Vet J ; 61(9): 946-950, 2020 09.
Article in English | MEDLINE | ID: mdl-32879518

ABSTRACT

A 9-year-old spayed female Cane Corso dog was presented with a 1-week history of an acute right hind limb non-weight-bearing lameness. Six years previously, a right tibial tuberosity advancement (TTA) procedure had been performed. Orthogonal radiographs of the right pelvic limb taken before presentation revealed a comminuted displaced mid-diaphyseal tibial fracture. An aggressive bone lesion with osteolysis and periosteal reaction of the proximal tibia were evident that were most consistent with a primary bone tumor. The owner elected to have the dog euthanized. After euthanasia a fine-needle aspirate of the right proximal tibia was submitted for clinical pathology. Cytology and alkaline phosphatase staining of the fine-needle aspirate were consistent with osteosarcoma. Key clinical message: To the authors' knowledge, this is only the second reported case of osteosarcoma at the site of a TTA. Implantassociated osteosarcoma has been associated with tibial plateau levelling osteotomy (TPLO) and fracture repair.


Une femelle Cane Corso stérilisée âgée de 9 ans fut présentée avec une histoire d'une boiterie sans appui de la patte arrière droite apparue de manière aiguë depuis 1 semaine. Six ans auparavant, une chirurgie d'avancement de la tubérosité tibiale droite (TTA) avait été réalisée. Des radiographies orthogonales du membre pelvien droit prises avant la présentation ont révélé une fracture comminutive déplacée du tibia au niveau mi-diaphysaire. Une lésion osseuse agressive avec ostéolyse et réaction du périoste du tibia proximal étaient évidentes et considérées compatibles avec une tumeur osseuse primaire. Le propriétaire opta pour l'euthanasie du chien. À la suite de l'euthanasie une aspiration à l'aiguille fine du tibia proximal droit fut soumise pour examen en pathologie clinique. La cytologie et une coloration à la phosphatase alcaline de l'aspiration à l'aiguille fine étaient compatibles avec un ostéosarcome.Message clinique clé :À la connaissance de l'auteur, ceci est seulement le deuxième cas rapporté d'un ostéosarcome au site d'une TTA. Les ostéosarcomes associés aux implants ont été associés avec l'ostéotome de nivellement du plateau tibial (TPLO) et la réparation de fracture.(Traduit par Dr Serge Messier).


Subject(s)
Dog Diseases , Osteosarcoma , Animals , Dog Diseases/diagnostic imaging , Dog Diseases/surgery , Dogs , Euthanasia, Animal , Female , Osteosarcoma/surgery , Osteosarcoma/veterinary , Osteotomy/veterinary , Stifle , Tibia/surgery
7.
Vet Surg ; 49(5): 879-883, 2020 Jul.
Article in English | MEDLINE | ID: mdl-32394507

ABSTRACT

OBJECTIVE: To evaluate whether formality of introduction differed between male vs female speakers at the 2018 American College of Veterinary Surgeons (ACVS) scientific meeting and identify other variables that predisposed introducers or chairs to informal introduction. STUDY DESIGN: Observational study. SAMPLE POPULATION: Thirteen session chairs introducing 68 lectures (41 by females, 27 by males) by 63 speakers. METHODS: Observers recorded the session introducer, speaker, and whether speakers were introduced with a formal or informal title. Information evaluated included type of oral presentation; introducer gender, year, and country of graduation from veterinary school; speaker gender; whether the speaker was a resident; and speaker's year of graduation. RESULTS: Female speakers were introduced by their first name in 9 of 41 introductions compared to in 1 of 27 introductions for male speakers. This difference reached statistical significance when data independence was assumed (P = .043); however, this significance was narrowly lost when data clustering on session introducer was controlled for (P = .067). CONCLUSION: In this study, female speakers were more likely than male speakers to be introduced by their first and last names rather than with their professional title at a recent ACVS scientific meeting. IMPACT: Additional research is required to determine the effect of this type of subordinate language and gender bias in veterinary surgery.


Subject(s)
Congresses as Topic/statistics & numerical data , Sexism/statistics & numerical data , Societies, Medical/statistics & numerical data , Female , Humans , Male , Veterinary Medicine
8.
Vet Comp Oncol ; 18(4): 599-606, 2020 Dec.
Article in English | MEDLINE | ID: mdl-32141158

ABSTRACT

Veterinary studies have reported the outcome of adrenalectomies in dogs; however, these studies typically include a wide variety of adrenal tumour sizes, including cases with or without vascular invasion. The purpose of this study was to report outcome in a cohort of dogs with histologically confirmed small adrenal tumours without vascular invasion treated with adrenalectomy. This retrospective study was conducted using data from the University of Florida and University of California-Davis databases between 2010 and 2017. Dogs were included if they underwent excision of an adrenal gland tumour with a maximal diameter ≤ 3 cm, without evidence of vascular invasion to any location as assessed via computed tomography. Fifty-one dogs met the inclusion criteria. The short-term survival rate of dogs undergoing adrenalectomy was 92.2%, and one-year disease-specific survival was 83.3%. Twenty-eight of 51 (54.9%) dogs were diagnosed with a malignancy. Minor complications were observed commonly intra-operatively and post-operatively. Major complications were observed in six dogs, and included sudden death, respiratory arrest, acute kidney injury, haemorrhage, hypotension and aspiration pneumonia. Short-term mortality occurred in four dogs. Sudden death and haemorrhage were the most common major complications leading to death. While adrenalectomy is sometimes controversial because of the high perioperative mortality rates previously reported, the results of this study support that adrenalectomy for small tumours with no vascular invasion can be performed with low risk.


Subject(s)
Adrenal Gland Neoplasms/veterinary , Dog Diseases/mortality , Dog Diseases/pathology , Postoperative Complications/veterinary , Adrenal Gland Neoplasms/mortality , Adrenal Gland Neoplasms/pathology , Adrenal Gland Neoplasms/surgery , Adrenalectomy/methods , Adrenalectomy/veterinary , Animals , California/epidemiology , Cohort Studies , Databases, Factual , Dog Diseases/diagnostic imaging , Dog Diseases/surgery , Dogs , Florida/epidemiology , Postoperative Complications/epidemiology , Postoperative Complications/mortality , Retrospective Studies , Risk Factors , Treatment Outcome
9.
Vet Surg ; 49(4): 811-817, 2020 May.
Article in English | MEDLINE | ID: mdl-31602683

ABSTRACT

OBJECTIVE: To report surgical and postoperative management of complicated total cystectomy in a dog with transitional cell carcinoma (TCC). STUDY DESIGN: Case report. ANIMALS: One male neutered Shetland sheepdog. METHODS: The dog was presented after a 1-month history of stranguria, unresponsive to oral antibiotic therapy. A craniodorsal bladder mass was identified by computed tomography (CT), and partial cystectomy was performed with 1-cm gross lateral margins (day 1). Results of histopathology provided evidence for a diagnosis of TCC, and the dog was treated with adjuvant mitoxantrone. The dog presented with uroperitoneum on day 67 after recurrence and spontaneous perforation. Total cystectomy and ureterourethral anastomosis were performed. Ureteral obstruction developed after removal of catheters that had been placed intraoperatively. Surgical revision included resection of the anastomosis site, bilateral ureteral stenting, and transection and reorientation of the distal urethra to facilitate tension-free closure. Postoperative leakage was managed with bilateral percutaneous nephrostomy tube placement. RESULTS: The dog was discharged on day 88. Adjuvant treatment with vinblastine was pursued. Local recurrence was noted at day 154. Subcutaneous ureteral bypass was performed on day 247 to manage repeat obstruction. Repeated urinary tract infections were subsequently encountered. The dog was euthanized on day 368 because of abdominal discomfort and inappetence, with evidence of progressive urethral, ureteric, and abdominal wall TCC. CONCLUSION: Complicated cystectomy can be managed to provide survival comparable to previous reports regarding total cystectomy. CLINICAL SIGNIFICANCE: Nephrostomy tube placement, ureteral stenting, and subcutaneous ureteral bypass may be considered to manage complicated cystectomy. Preemptive stenting or urinary diversion may help prevent complications.


Subject(s)
Carcinoma, Transitional Cell/veterinary , Cystectomy/veterinary , Dog Diseases/surgery , Postoperative Complications/veterinary , Urinary Bladder Neoplasms/veterinary , Animals , Carcinoma, Transitional Cell/diagnosis , Carcinoma, Transitional Cell/surgery , Cystectomy/adverse effects , Dog Diseases/diagnosis , Dogs , Male , Postoperative Complications/therapy , Treatment Outcome , Urinary Bladder Neoplasms/diagnosis , Urinary Bladder Neoplasms/surgery
10.
Vet Surg ; 49(3): 607-613, 2020 Apr.
Article in English | MEDLINE | ID: mdl-31605496

ABSTRACT

OBJECTIVE: To report the surgical technique for iliectomy and outcome in a single clinical case. STUDY DESIGN: Case report. ANIMAL: A 10-year-old female spayed Rottweiler. METHODS: A dog presented with left pelvic limb lameness due to a mass involving the left ilium. Fine needle aspirates were indicative of a sarcoma and suspicious for osteosarcoma. Computed tomography of thorax, abdomen, and pelvis was performed as well as skeletal scintigraphy, with no evidence of metastasis seen. The dog underwent iliectomy with preservation of the ipsilateral limb and was ambulatory 24 hours after surgery. Results of histopathology confirmed the diagnosis of an osteosarcoma. RESULTS: A right ischial fracture was noted 8 days postoperatively and was conservatively managed. Local recurrence was reported 385 days postoperatively, with no overt metastatic disease revealed by computed tomography of the thorax and abdomen. The dog was euthanized because of local recurrence 430 days after surgery. CONCLUSION: Iliectomy was well tolerated in this dog and afforded good function of the pelvic limbs. Local recurrence developed with no evidence of metastasis at the last follow-up. Iliectomy can be considered for a mass confined to the ilium when preservation of the limb is desired. Additional studies are required to determine the local recurrence and complication rates associated with this procedure in dogs with axial skeletal osteosarcoma. CLINICAL SIGNIFICANCE: To the authors' knowledge, this case report represents the fist surgical description and clinical outcome for an iliectomy in dogs.


Subject(s)
Bone Neoplasms/veterinary , Dog Diseases/surgery , Ilium/pathology , Osteosarcoma/veterinary , Animals , Bone Neoplasms/surgery , Dogs , Female , Fractures, Bone/veterinary , Neoplasm Recurrence, Local/veterinary , Osteosarcoma/surgery
11.
Vet Surg ; 49(1): 222-232, 2020 Jan.
Article in English | MEDLINE | ID: mdl-31738456

ABSTRACT

OBJECTIVE: To report outcomes after radical mandibulectomy in cats. STUDY DESIGN: Multi-institutional retrospective study. ANIMALS: Eight cats were included. METHODS: Medical records were searched for cats with confirmed oral neoplasia treated with radical mandibulectomy. Data collected included demographics, surgical procedure, histopathological diagnosis, postoperative management, and outcomes. RESULTS: Ages ranged from 8 to 17 years. All cats had 75% to 90% of the mandible removed and feeding tubes placed. Seven cats had squamous cell carcinoma, and one cat had a giant cell tumor. Six cats ate on their own postoperatively. Three cats had local recurrence and tumor-related died at 136 and 291 days. Six cats had no recurrence, with survival times of 156, 465, 608, and 1023 days, and two cats were still alive at 316 and 461 days after surgery. The three long-term survivors died of causes unrelated to oral neoplasia. One cat died at 156 days due to aspiration of food material. The overall estimated mean survival time was 712 days. CONCLUSION: After radical mandibulectomy, independent food intake was achieved in 6 of eight cats, and four cats lived longer than one year. CLINICAL SIGNIFICANCE: Radical mandibulectomy should be considered for the treatment of extensive oral neoplasia in cats. Successful long-term outcomes are possible with aggressive supportive care perioperatively.


Subject(s)
Carcinoma, Squamous Cell/veterinary , Cat Diseases/surgery , Giant Cell Tumors/veterinary , Mandibular Osteotomy/veterinary , Mouth Neoplasms/veterinary , Animals , Carcinoma, Squamous Cell/surgery , Cats , Female , Giant Cell Tumors/surgery , Male , Mouth Neoplasms/surgery , Retrospective Studies , Survival Rate , Treatment Outcome
12.
Can Vet J ; 60(7): 757-761, 2019 Jul.
Article in English | MEDLINE | ID: mdl-31281194

ABSTRACT

The objective of this report was to document a successful partial limb amputation surgery in a cat with metatarsal osteosarcoma (OSA) including the use of pad grafts from the amputated foot. Limb shortening of the hindlimb through a partial amputation resulted in excellent limb function and usage. The patient retained functional use of the limb after surgery, with no lameness. There was no evidence of metastasis or local recurrence seen 323 days post-surgery. Limb shortening partial amputation is a reasonable option and can result in excellent limb use after surgery despite a significant loss in limb length.


Intervention pour raccourcir et sauver un membre chez un chat atteint d'un ostéosarcome métatarsien. L'objectif du présent rapport consistait à documenter une chirurgie d'amputation partielle réussie chez un chat atteint d'un ostéosarcome métatarsien y compris l'usage de greffes des coussinets du pied amputé. Le raccourcissement du membre postérieur par une amputation partielle a donné d'excellents résultats pour la fonction et l'usage du membre. Le patient a conservé l'usage fonctionnel du membre après la chirurgie, sans boiterie. Il n'y avait aucun signe de métastase ni de récurrence locale lors d'un examen 323 jours après la chirurgie. L'amputation partielle et le raccourcissement du membre sont une option raisonnable et peuvent produire une excellente utilisation du membre après la chirurgie malgré une perte importante de la longueur du membre.(Traduit par Isabelle Vallières).


Subject(s)
Bone Neoplasms/surgery , Bone Neoplasms/veterinary , Cat Diseases , Metatarsal Bones , Osteosarcoma/surgery , Osteosarcoma/veterinary , Amputation, Surgical/veterinary , Animals , Cat Diseases/surgery , Cats , Limb Salvage/veterinary , Neoplasm Recurrence, Local/veterinary , Treatment Outcome
13.
Vet Clin North Am Small Anim Pract ; 49(5): 793-807, 2019 Sep.
Article in English | MEDLINE | ID: mdl-31147188

ABSTRACT

Clinical staging is important for determining the extent of disease in animals with malignant cancers. The status of the lymph node will help determine whether adjuvant treatment is indicated. Historically, the regional anatomic lymph node has been sampled to determine the presence or absence of metastatic disease, but there is increasing evidence that the regional anatomic lymph node is often different to the sentinel lymph node. As a result, several sentinel lymph node mapping techniques have been described for more accurate clinical staging of oncologic patients.


Subject(s)
Dog Diseases/diagnosis , Sentinel Lymph Node Biopsy/veterinary , Sentinel Lymph Node/diagnostic imaging , Animals , Contrast Media , Dogs , Humans , Lymph Node Excision/methods , Lymph Node Excision/veterinary , Lymphography/methods , Lymphography/veterinary , Sentinel Lymph Node Biopsy/methods , Ultrasonography/methods , Ultrasonography/veterinary
14.
Vet Surg ; 48(5): 742-750, 2019 Jul.
Article in English | MEDLINE | ID: mdl-31034643

ABSTRACT

OBJECTIVE: To report the morbidity and mortality associated with adrenalectomy with cavotomy for resection of invasive adrenal neoplasms in dogs and evaluate risk factors for perioperative outcomes. STUDY DESIGN: Retrospective study. ANIMALS: Forty-five client-owned dogs. METHODS: Dogs that underwent open adrenalectomy with cavotomy for resection of adrenal masses with tumor thrombus extending into the vena cava were included. Clinicopathologic data were harvested from medical records. Selected clinical, imaging, and operative variables were statistically evaluated as risk factors for packed red blood cell transfusion, nephrectomy, perioperative death, and overall survival. RESULTS: Thirty-six of 45 masses were pheochromocytomas, 7 were adrenocortical carcinomas, and 2 were unknown type. Caval thrombus terminated prehepatically in 21 of 45 dogs and extended beyond the porta hepatis but terminated prediaphragmatically (intrahepatic prediaphragmatic location) in 15 dogs and thrombi extended postdiaphragmatically in 5 dogs. Thirty-four (76%) dogs were discharged from the hospital, and 11 (24%) dogs died or were euthanized prior to discharge. Median overall survival time for all 45 dogs was 547 days (95%CI 146-710). Bodyweight, tumor type, and size and extent of caval thrombus did not affect survival to discharge, but postdiaphragmatic (rather than prediaphragmatic) thrombus termination was associated with a greater risk of death. CONCLUSION: Long-term survival was common in dogs that survived the perioperative period. Postdiaphragmatic thrombus extension affected the prognosis for overall survival. CLINICAL SIGNIFICANCE: Findings of this study help to stratify operative risk in dogs with adrenal neoplasia and caval invasion.


Subject(s)
Adrenal Gland Neoplasms/veterinary , Adrenalectomy/veterinary , Adrenocortical Carcinoma/veterinary , Dog Diseases/surgery , Pheochromocytoma/veterinary , Adrenal Gland Neoplasms/surgery , Adrenocortical Carcinoma/surgery , Animals , Dogs , Female , Humans , Kidney Neoplasms/surgery , Kidney Neoplasms/veterinary , Male , Nephrectomy/methods , Nephrectomy/veterinary , Postoperative Complications/veterinary , Prognosis , Retrospective Studies , Risk Factors
15.
J Vet Intern Med ; 33(2): 792-799, 2019 Mar.
Article in English | MEDLINE | ID: mdl-30835925

ABSTRACT

BACKGROUND: Body surface area (BSA) can reflect metabolic rate that might normalize dosing of chemotherapeutics across widely variable weights within a species. The current BSA formula for dogs lacks height, length, and body condition. HYPOTHESIS: Computed tomography (CT) imaging will allow inclusion of morphometric variables in allometric modeling of BSA in dogs resulting in an improved formula for BSA estimation. ANIMALS: Forty-eight dogs from 4 institutions with whole-body CT images. METHODS: Retrospective and prospective case series. Body surface area was contoured using whole-body CT scans and radiation therapy planning software. Body length and height were determined from CT images and also in 9 dogs by physical measurement. Nonlinear regression was used to model the BSA data sets using allometric equations. Goodness-of-fit criteria included average relative deviation, mean standard error, Akaike information criterion, and r2 (derived from the r-value generated by regression models). RESULTS: Contoured BSA differed from the current formula by -9% to +19%. Nonlinear regression on untransformed data yielded BSA = 0.0134 × body weight [kg]∧ 0.4746 × length (cm)∧ 0.6393 as the best-fit model. Heteroscedasticity (increasing morphometric variability with increasing BSA) was an important finding. CONCLUSIONS AND CLINICAL IMPORTANCE: Computed tomography-derived BSA was used to incorporate body length into a novel BSA formula. This formula can be applied prospectively to determine whether it correlates with adverse events attributed to chemotherapy.


Subject(s)
Body Surface Area/veterinary , Dogs/anatomy & histology , Tomography, X-Ray Computed/methods , Animals , Body Weight , Female , Male , Prospective Studies , Regression Analysis , Retrospective Studies , Software
16.
Vet Surg ; 48(3): 367-374, 2019 Apr.
Article in English | MEDLINE | ID: mdl-30666680

ABSTRACT

OBJECTIVE: To report perioperative characteristics, complications, histopathologic diagnosis and outcome in cats undergoing surgical treatment for primary hyperparathyroidism (PHPT). STUDY DESIGN: Multi-institutional, retrospective case series. ANIMALS: Thirty-two client-owned cats. METHODS: Medical records of cats treated with surgical removal of 1 or more parathyroid gland(s) with confirmed histopathologic evaluation were reviewed. Cats were divided into preoperative ionized calcium (iCa) groups corresponding to the 33rd, 67th, and 100th percentiles of the preoperative iCa results of the study population. Follow-up consisted of phone conversation with owners or primary veterinarian. RESULTS: Ionized calcium was above reference range in all cats (median 1.8 mmol/L [interquartile range, 1.5-1.9]). Abnormal tissue was excised after cervical exploration in all cats. The most common histopathologic diagnoses were parathyroid adenoma in 20 of 32 (62.5%) cats and parathyroid carcinoma in 7 of 32 (21.9%) cats. At discharge, 6 of 32 (18.8%) cats had hypercalcemia, 5 of 32 (15.6%) had hypocalcemia, and 21 of 32 (65.6%) were normocalcemic. Preoperative iCa did not correlate with postoperative iCa. The median follow-up time was 332 days (range, 7-3156). Overall median survival time was 1109 days (95% CI, 856-1332). Survival time was not associated with preoperative iCa group, hypocalcemia at discharge, hypercalcemia at discharge, or diagnosis of carcinoma. CONCLUSION: In this cohort of cats, parathyroid adenoma was the most common cause of PHPT, and surgical treatment resulted in very good median survival time. Preoperative iCa was not predictive of postoperative hypocalcemia. CLINICAL SIGNIFICANCE: Surgical parathyroidectomy for treatment of PHPT in cats provides a favorable prognosis.


Subject(s)
Cat Diseases/surgery , Hyperparathyroidism, Primary/veterinary , Parathyroidectomy/veterinary , Perioperative Period/veterinary , Animals , Calcium/blood , Cat Diseases/blood , Cats , Female , Humans , Hyperparathyroidism, Primary/surgery , Male , Retrospective Studies , Treatment Outcome
17.
Vet Surg ; 48(S1): O91-O98, 2019 Jun.
Article in English | MEDLINE | ID: mdl-30666685

ABSTRACT

OBJECTIVE: To determine laparoscopic accessibility of liver lobes and access to the hilus and describe laparoscopic microwave ablation (LMWA) in 2 dogs with hepatic neoplasia. STUDY DESIGN: Experimental/descriptive case series. SAMPLE POPULATION: Six canine cadavers and 2 clinical dogs. METHODS: Cadavers in dorsal recumbency underwent laparoscopic assessment of the liver. A 17 gauge MWA probe was inserted to create an ablation zone at the most proximal aspect of the hilus. The distance from the center of each ablation zone to the most proximal aspect of the corresponding hilus was determined. Two dogs with hepatic neoplasia underwent LMWA. RESULTS: All lobes of the canine liver were accessible via laparoscopy. The median (interquartile range) distances from the ablation zones to the hilus for the caudate process, left lateral, left middle, quadrate, right lateral, and right middle lobes were 2.2 (1.2-2.6), 2.1 (1-4.4), 1.5 (1.4-3.7), 2, 1, 2.5 (1-4.1) cm, respectively. Histopathologic diagnoses treated by LMWA included metastatic hemangiosarcoma and primary hepatocellular carcinoma. Laparoscopic microwave ablation was technically feasible, and no complications from the procedure resulted. CONCLUSION: Laparoscopic access to the hilus of each liver lobe is possible via a ventrodorsal approach provided reverse Trendelenburg and lateral rotation is used, especially for the right lateral lobe. Laparoscopic microwave ablation is feasible in some dogs with hepatic neoplasia. The indications for and efficacy of LMWA for hepatic neoplasia in dogs requires additional investigation. CLINICAL SIGNIFICANCE: Laparoscopic access to all liver lobes and MWA of some neoplastic lesions is feasible in a canine pilot study.


Subject(s)
Carcinoma, Hepatocellular/veterinary , Liver Neoplasms/veterinary , Microwaves , Radiofrequency Ablation/veterinary , Animals , Carcinoma, Hepatocellular/surgery , Dogs , Hemangiosarcoma/surgery , Laparoscopy/methods , Liver Neoplasms/surgery , Male , Pilot Projects , Treatment Outcome
18.
Can Vet J ; 59(10): 1096-1098, 2018 10.
Article in English | MEDLINE | ID: mdl-30510315

ABSTRACT

This report describes a domestic shorthair cat with fracture-associated osteosarcoma 11 years after injury. A left hind limb amputation was performed using coxofemoral disarticulation. No intravenous cytotoxic chemotherapy was used after surgery. Pulmonary metastasis was identified 3 months after amputation. Fracture-associated osteosarcoma may occur in the cat more than 10 years after initial injury.


Ostéosarcome du fémur associé à une fracture chez un chat. Ce rapport décrit un chat commun domestique atteint d'un ostéosarcome associé à une fracture 11 ans après la blessure. Une amputation du membre arrière gauche a été réalisée à l'aide de la désarticulation coxofémorale. Aucune chimiothérapie cytotoxique intraveineuse n'a été utilisée après la chirurgie. La métastase pulmonaire a été identifiée 3 mois après l'amputation. Un ostéosarcome associé à une fracture peut se produire chez le chat plus de 10 ans après la blessure initiale.(Traduit par Isabelle Vallières).


Subject(s)
Bone Neoplasms/veterinary , Cat Diseases/etiology , Femur/pathology , Fractures, Bone/veterinary , Osteosarcoma/veterinary , Amputation, Surgical/veterinary , Animals , Bone Neoplasms/complications , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/surgery , Cat Diseases/surgery , Cats , Femur/injuries , Fractures, Bone/complications , Lung Neoplasms/secondary , Lung Neoplasms/veterinary , Male , Osteosarcoma/complications , Osteosarcoma/diagnostic imaging , Osteosarcoma/surgery
19.
Can Vet J ; 59(11): 1187-1194, 2018 11.
Article in English | MEDLINE | ID: mdl-30410175

ABSTRACT

The objectives of this study were to describe the sartorius muscle flap for body wall reconstruction, including description of the anatomy and surgical technique and to report its clinical application for abdominal wall reconstruction in dogs and cats. The descriptive report involves a retrospective case series for 2 dogs and 3 cats. Inclusion criteria were cats or dogs that had a tumor resection resulting in an abdominal wall defect that was reconstructed using an ipsilateral or contralateral sartorius muscle flap. Signalment, pre-operative clinical signs, location and tumor extent, diagnostic imaging and clinical pathology findings, surgical methods, and complications were recorded. Abdominal wall defect reconstructions using the sartorius muscle flap were successfully performed in all 5 patients with good return to function. All complications were minor and were successfully medically managed. This case series demonstrates that the sartorius muscle flap is a feasible option for the closure of large caudal abdominal wall defects.


Rabat du muscle sartorius pour la reconstruction de la paroi du corps: description de la technique chirurgicale et série de cas rétrospectifs. Les objectifs de cette étude étaient de décrire le rabat du muscle sartorius pour la reconstruction de la paroi du corps, y compris la description de l'anatomie et de la technique chirurgicale et de faire rapport sur son application clinique pour la reconstruction de la paroi abdominale des chiens et des chats. Le rapport descriptif porte sur une série de cas rétrospectifs pour 2 chiens et 3 chats. Les critères d'inclusion étaient des chats ou des chiens ayant subi une résection de tumeur qui avait produit un défaut de la paroi abdominale qui avait été reconstruite à l'aide d'un rabat du muscle sartorius ipsilatéral ou contralatéral. Le signalement, les signes cliniques avant l'opération, l'emplacement et l'étendue de la tumeur, les résultats de l'imagerie diagnostique et de la pathologie clinique, les méthodes chirurgicales et les complications ont été consignés. Les reconstructions du défaut de la paroi abdominale en utilisant le rabat du muscle sartorius ont été réalisées avec succès chez les 5 patients avec un bon retour de fonction. Toutes les complications étaient mineures et ont été médicalement gérées avec succès. Cette série de cas démontre que le rabat du muscle sartorius représente une option possible pour la fermeture de larges défauts de la paroi abdominale caudale.(Traduit par Isabelle Vallières).


Subject(s)
Abdominal Wall/surgery , Cat Diseases/surgery , Dog Diseases/surgery , Plastic Surgery Procedures/veterinary , Surgical Flaps/veterinary , Animals , Cats , Dogs , Female , Hindlimb , Male , Muscle, Skeletal , Neoplasms/surgery , Neoplasms/veterinary , Plastic Surgery Procedures/methods , Retrospective Studies
20.
Vet Surg ; 47(6): 774-783, 2018 Aug.
Article in English | MEDLINE | ID: mdl-30051473

ABSTRACT

OBJECTIVE: To define and compare clinical characteristics of canine primary appendicular hemangiosarcoma (HSA) and telangiectatic osteosarcoma (tOSA), including signalment, presentation, response to treatment, and prognosis. STUDY DESIGN: Multi-institutional retrospective study. ANIMALS: Seventy dogs with primary appendicular HSA or tOSA. METHODS: Patient data were obtained from institutions' medical records. Immunohistochemistry was applied to archived tissues to establish tumor type. Patient characteristics, treatment responses, and outcomes were described and compared by tumor type. RESULTS: Forty-one HSA and 29 tOSA were identified. Dogs with HSA were more likely than dogs with tOSA to be male and have hind limb tumors; 78% of HSA occurred in hind limbs, particularly the tibia. Dogs with tOSA weighed a median of 9.9 kg (95% CI 4.6-15.3) more than dogs with HSA. Most dogs received antineoplastic treatment, predominantly amputation with or without adjuvant chemotherapy. Overall survival with local treatment and chemotherapy was 299 days (95% CI 123-750) for HSA and 213 days (95% CI 77-310) for tOSA. Younger age and more aggressive treatment were associated with longer survival in dogs with HSA but not tOSA. One-year survival rates did not differ between dogs with HSA (28%) and those with tOSA (7%). CONCLUSION: Distinct clinical features were identified between HSA and tOSA in this population. Both tumors were aggressive, with a high incidence of pulmonary metastases. However, local treatment combined with chemotherapy led to an average survival 7 months for tOSA and 10 months for HSA. CLINICAL SIGNIFICANCE: HSA should be considered as a differential in dogs with aggressive lytic bone lesions, particularly medium-sized dogs with tibial lesions. HSA has a unique clinical presentation but similar therapeutic response and outcome to OSA. Amputation and chemotherapy appear to prolong survival in some dogs with HSA and tOSA.


Subject(s)
Dog Diseases/therapy , Hemangiosarcoma/veterinary , Osteosarcoma/veterinary , Animals , Dog Diseases/surgery , Dogs , Female , Hemangiosarcoma/surgery , Hemangiosarcoma/therapy , Male , Osteosarcoma/surgery , Osteosarcoma/therapy , Retrospective Studies
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